MONOCLONAL ANTIBODIES FOR THE RAPID DIAGNOSIS OF INFLUENZA A AND B VIRUS INFECTIONS BY IMMUNOFLUORESCENCE
Identifieur interne : 002433 ( Main/Exploration ); précédent : 002432; suivant : 002434MONOCLONAL ANTIBODIES FOR THE RAPID DIAGNOSIS OF INFLUENZA A AND B VIRUS INFECTIONS BY IMMUNOFLUORESCENCE
Auteurs : J. Mcquillin [Royaume-Uni] ; C. R Madeley [Royaume-Uni] ; A. P Kendal [États-Unis]Source :
- The Lancet [ 0140-6736 ] ; 1985.
English descriptors
- Teeft :
- Acceptable quality, Antibody, Antiserum, Baboon kidney cells, Cell cultures, Clin microbiol, Clinical specimens, Human kidney, Immunofluorescence, Indirect immunofluorescence, Influenza, Intranuclear fluorescence, Kidney antigens, Mcquillin, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Monoclonal hybridoma antibodies, Monoclonal pool, Monoclonal pools, Nasopharyngeal, Nasopharyngeal secretion, Nasopharyngeal secretions, Polyclonal, Polyclonal rabbit antiserum, Preliminary testing, Rapid diagnosis, Rapid virus diagnosis, Reproducible quality, Respiratory syncytial virus, Royal victoria infirmary, Satisfactory results, Secretion, Specific fluorescence, Specific influenza, Sputum specimens, Sublethal dose, Summary introduction, Technical assistance, Urinary excretion, Virus infections, World health organisation.
Abstract
Abstract: Mouse monoclonal antibodies, directed against antigenic sites on influenza A and B viruses and found to be type-specific in an immunoassay, were assessed for use as diagnostic reagents in an indirect immunofluorescence assay on nasopharyngeal secretions. The influenza A antibodies were directed against nucleoprotein or matrix protein antigens and the influenza B antibodies against nucleoprotein and haemagglutinin antigens. The influenza A anti-matrix monoclonal antibody was found to give a strong intranuclear particulate fluorescence in normal baboon kidney cells and cells from nasopharyngeal secretions negative for influenza A virus, including those from a patient infected with respiratory syncytial virus. Pools of the remaining monoclonal antibodies gave satisfactory results on 25 specimens from patients with influenza A H1N1 and H3N2 subtypes and 12 from patients with influenza B.
Url:
DOI: 10.1016/S0140-6736(85)90849-9
Affiliations:
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The influenza A antibodies were directed against nucleoprotein or matrix protein antigens and the influenza B antibodies against nucleoprotein and haemagglutinin antigens. The influenza A anti-matrix monoclonal antibody was found to give a strong intranuclear particulate fluorescence in normal baboon kidney cells and cells from nasopharyngeal secretions negative for influenza A virus, including those from a patient infected with respiratory syncytial virus. Pools of the remaining monoclonal antibodies gave satisfactory results on 25 specimens from patients with influenza A H1N1 and H3N2 subtypes and 12 from patients with influenza B.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Mcquillin, J" sort="Mcquillin, J" uniqKey="Mcquillin J" first="J" last="Mcquillin">J. Mcquillin</name></noRegion><name sortKey="Madeley, C R" sort="Madeley, C R" uniqKey="Madeley C" first="C. 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